2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W504836
    Deuteroporphyrin IX dihydrochloride 68929-05-5 98%
    Deuteroporphyrin IX (dihydrochloride) is a photosensitizer with high lipophilicity and amphiphilicity, capable of providing photosensitivity for cell membrane systems. Deuteroporphyrin IX (dihydrochloride) can induce irreversible discharge elimination in individual neurons.
    Deuteroporphyrin IX dihydrochloride
  • HY-W506356
    2,3-MDMA hydrochloride 168968-01-2 98%
    2,3-MDMA hydrochloride is a noradrenalin transporter and serotonin transporter inhibitor with IC50 values of 6.2 μM and 82 μM, respectively.
    2,3-MDMA hydrochloride
  • HY-W509563
    Frataxin-IN-1 102616-64-8 98%
    Frataxin-in-1 (Compound (+)-11) is a Frataxin inhibitor with IC50 value of 45 μM, which can be used in the study of Friedreich's ataxia (FRDA).
    Frataxin-IN-1
  • HY-W539944
    Argipressin acetate 129979-57-3 98%
    Argipressin (Arg8-vasopressin) (acetate) binds to the V1, V2, V3-vascular arginine vasopressin receptor, with a Kd value of 1.31 nM in A7r5 rat aortic smooth muscle cells for V1.
    Argipressin acetate
  • HY-W550739
    Acesulfame 33665-90-6 98%
    Acesulfame is an artificial sweetener. Acesulfame affects cognitive functions, potentially via altering neuro-metabolic functions in mice with long-term.
    Acesulfame
  • HY-W587881
    Acetylvardenafil 1261351-28-3 98%
    Acetylvardenafil is a new analog of Vardenafil (HY-B0442). The sulfonyl group in the structure of Acetylvardenafil is replaced by an acetyl group. Acetylvardenafil is a PDE-5 inhibitor that can be used in the study of erectile dysfunction (ED).
    Acetylvardenafil
  • HY-W596782
    Chaetochromin A 75514-37-3 98%
    Chaetochromin A (Compound 1) is a fungal metabolite. Chaetochromin A shows inhibitory effect on botulinum neurotoxin serotype A (BoNT A) (IC50= 24.6 μM).
    Chaetochromin A
  • HY-W634748
    Desalkylgidazepam 2894-61-3 98%
    Desalkylgidazepam is a benzodiazepine compound and Gidazepam (HY-U00315) metabolite. Desalkylgidazepam can activate GABA A receptor and translocator protein (TSPO).
    Desalkylgidazepam
  • HY-W653905
    Amantadine-d15 hydrochloride 98%
    Amantadine-d15 hydrochloride is deuterated labeled Amantadine. Amantadine (1-Adamantanamine) is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion channels. Amantadine also has anti-orthopoxvirus and anticancer activity. Amantadine can be used for Parkinson's disease, postoperative cognitive dysfunction (POCD) and COVID-19 research.
    Amantadine-d15 hydrochloride
  • HY-W653958
    Oxybenzone-d3 98%
    Oxybenzone-d3 (Benzophenone 3-d3) is a deuterium labeled Oxybenzone (HY-A0067). Oxybenzone (Benzophenone 3) is a commonly used UV filter in sun tans and skin protectants. Oxybenzone act as endocrine disrupting chemicals (EDCs) and can pass through the placental and blood-brain barriers. Benzophenone-3 impairs autophagy, alters epigenetic status, and disrupts retinoid X receptor signaling in apoptotic neuronal cells.
    Oxybenzone-d3
  • HY-W654010
    Lurasidone-d8-1 hydrochloride 98%
    Lurasidone-d8-1 (hydrochloride) is deuterium labeled Lurasidone (Hydrochloride). Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride)) is an antagonist of both dopamine D2 and 5-HT7 with IC50s of 1.68 and 0.495 nM, respectively. Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride)) is also a partial agonist of 5-HT1A receptor with an IC50 of 6.75 nM.
    Lurasidone-d8-1 hydrochloride
  • HY-W659059
    N-Methyl-1-phenylpropan-1-amine hydrochloride 76605-79-3 98%
    N-Methyl-1-phenylpropan-1-amine hydrochloride is structurally categorized as a benzylamine.
    N-Methyl-1-phenylpropan-1-amine hydrochloride
  • HY-W664041
    Noncatechol agonist-1 1609580-99-5 98%
    Noncatechol agonist-1 (19) is a Noncatechol agonist with full efficacy at both D1R-G protein and D1R-β-arrestin2 pathways, with pEC50 values of 8.41 for D1R-mediated cAMP production and 7.7 for β-arrestin2 recruitment, respectively.
    Noncatechol agonist-1
  • HY-W677042
    α-Androstenol 1153-51-1 98%
    α-Androstenol (5α-Androst-16-en-3α-ol) is a steroid pheromone that has been found in boar testes and human male axillary sweat. α-Androstenol is also a positive modulator of GABAA receptors, which enhances GABA-activated currents in primary mouse cerebellar granule cells (EC50=0.4 μM). α-Androstenol decreases immobility time in the forced swim test and increases time spent in the open arms of the elevated plus maze in mice. α-Androstenol protects against seizures induced by Pentylenetetrazole or electroshock with anxiolytic-like activity in mice.
    α-Androstenol
  • HY-W680647
    MDL 72527 free base 99207-33-7 98%
    MDL 72527 free base is a potent polyamine oxidase (PAO) inhibitor. MDL 72527 free base shows a lysosomotropic effect. MDL 72527 shows neuroprotective effects.
    MDL 72527 free base
  • HY-W681014
    5-Fluoro-α-methyltryptamine hydrochloride 776-56-7 98%
    5-Fluoro-α-methyltryptamine hydrochloride may cause an increase in intracellular levels of 5-HT followed by an increase in 5-HT release. 5-Fluoro-α-methyltryptamine hydrochloride exhibits EC50 values of 37 nM, 14 nM, 78 nM and 8.47 nM for DA, 5HT, NE and 5-HT2A, respectively.
    5-Fluoro-α-methyltryptamine hydrochloride
  • HY-W681071
    BRS-3 receptor agonist-2 1021937-07-4 98%
    BRS-3 receptor agonist-2 (compound 2) is a potent BRS-3 receptor agonist, with an EC50 of 2.5 nM for mouse BRS-3 receptor.
    BRS-3 receptor agonist-2
  • HY-W681674
    para-Methylaminorex 959249-62-8 98%
    para-Methylaminorex is structurally similar to known stimulants.
    para-Methylaminorex
  • HY-W686216
    VK-28 312611-92-0
    VK-28, a brain-permeable iron chelator, inhibits both basal and Fe/ascorbate-induced mitochondrial membrane lipid peroxidation, with an IC50 of 12.7 μM. VK-28 exhibits significant neuroprotective effects on ICV-6-OHDA. VK-28 can be used for the research of Parkinson’s disease and other neurodegenerative diseases.
    VK-28
  • HY-W687950
    β-Phenyl GHB sodium 40951-19-7 98%
    β-Phenyl GHB sodium is structurally similar to known CNS depressants.
    β-Phenyl GHB sodium
Cat. No. Product Name / Synonyms Application Reactivity